During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP.These condensates move radially at the IS, traversing successive radially-oriented and concentric One Hitters actin networks.To understand this movement, we biochemically re
Low back pain is a major cause of disability worldwide that declines the quality of life; it poses a substantial economic burden for the patient and society.Intervertebral disc (IVD) degeneration (IDD) is the main cause of low back pain, and it is also the pathological basis of several spinal degenerative diseases, such as intervertebral disc herni
General-purpose computers have become ubiquitous and important for everyday life, but they are difficult for people with paralysis to use.Specialized software and personalized input devices can improve access, but often provide only limited functionality.In this study, three research participants with tetraplegia who had multielectrode arrays impla
An engineering design procedure for calculating bending with torsion in corrugated beams, including finding the critical load of general stability, hub implemented in the commonly used MS Excel spreadsheet and verified in the LIRA-SAPR software package, has been proposed.The method makes it possible to take into account the beams section variabilit
The first documented case of melioidosis in the Philippines occurred in 1948.Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines.Indigenous cases, however, have been documented rarely, and under-reporting is highly likely.This review collated all Philippine c